is endogenous prolactin, not endocrine prolactin, responsible for hyperparathyroidism in breast cancer patients?
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منابع مشابه
Prolactin concentrations in patients with breast cancer.
Basal prolactin levels were measured before operation in 113 patients undergoing surgery for a lump in the breast. Prolactin concentrations were not significantly higher in those patients with breast cancer than in those with benign lumps. Prolactin concentrations were, however, found to be higher in premenopausal women than in postmenopausal ones, regardless of tumour histology.
متن کاملProlactin involvement in breast cancer.
Normal development and differentiation of the mammary gland are profoundly influenced by prolactin (PRL). In rodent mammary cancer PRL plays a well defined role, but its role, in human breast cancer has not been appreciated until recently. It is now clear that breast tissue, both normal and malignant, is a significant source of extrapituitary PRL. Thus an autocrine/paracrine role of PRL in huma...
متن کاملEssential role of endogenous prolactin and CDK7 in estrogen-induced upregulation of the prolactin receptor in breast cancer cells
Our early studies have shown that Estradiol (E2)/Estrogen Receptor α (ER) in a non-DNA dependent manner through complex formation with C/EBPβ/SP1 induced transcriptional activation of the generic hPIII promoter and expression of the Prolactin Receptor (PRLR) receptor in MCF-7 cells. Subsequent studies demonstrated effects of unliganded ERα with requisite participation of endogenous PRL on the a...
متن کاملImportance of serum prolactin determination in metastatic breast cancer patients.
AIM To correlate prolactin concentrations in the sera of patients with metastatic breast cancer with time interval to appearance of metastases, their location, and size. METHOD The prospective study included 46 female patients with histologically confirmed diagnosis of breast cancer. The patients were recruited from the Health Center outpatient clinic and University Hospital Center day-care h...
متن کاملSerum prolactin responses to TRH in recurrent breast cancer patients.
The response of serum prolactin (PRL) to thyrotropin-releasing hormone (TRH) was evaluated by radioimmunoassay in 6 normal women and 44 breast cancer cases. They were divided into the following 5 groups: group 1:6 normal women; group 2:10 preoperative patients with early breast cancer; group 3:13 preoperative patients with advanced cancer; group 4:13 postoperative patients with no recurrence of...
متن کاملProlactin Receptor Isoforms in Human Breast Cancer
Prolactin (PRL) is a polypeptide hormone secreted by the anterior pituitary responsible for the growth and differentiation of the normal mammary gland and plays a role in breast cancer. It functions systemically as an endocrine factor, but PRL may also act in an autocrine/paracrine fashion in a number of other tissues. Studies in both preand post-menopausal women have determined a significant i...
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عنوان ژورنال:
archives of breast cancerجلد ۳، شماره ۳، صفحات ۷۴-۷۶
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